Saliva as a Potential Specimen to Monitor IL-6, TNF-α and IL-10 in COVID-19 PatientsArticle Published on 2022-12-012022-11-15 Journal: Inflammation [Category] COVID19(2023년), SARS, 치료기술, [키워드] alleviate Blood blood specimen Clinical prognosis collected comparable COVID-19 COVID-19 patients cycle threshold detectable elevated elicited enrolled expressed expression human saliva IL-10 IL-10. IL-6 inclusion criteria Infection Inflammation Inflammation. Inflammatory Inflammatory cytokine inflammatory gene Lung injury marker MINI Mortality Patient pilot study Potential protocols Qiagen RNA RT-PCR Saliva SARS-CoV-2 severe cases specimen subject the mean TNF-α were assessed [DOI] 10.1007/s10753-022-01698-x PMC 바로가기
Nitazoxanide and COVID-19: A reviewArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] SARS, 치료제, [키워드] Activation acute lung injury acute respiratory distress acute respiratory distress syndrome addition Anti-inflammatory anti-parasitic drug anti-SARS-CoV-2 Antiviral antiviral activity antiviral property ARDS autophagic cause cell death clinical trial Coronavirus disease 2019 COVID-19 Cytokine storm Cytokines distress drug effective finding IFN immunological in silico in vitro study Infection inflammatory disorders inflammatory reaction inhibit Innate immunity interferon lung mammalian mitigate Multi-organ damage nitazoxanide oxidative stress pathogenesis of SARS-CoV-2 pro-inflammatory cytokines pro-inflammatory cytokines. Prospective Study Protozoa Rapamycin reduce Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 infections severe cases syndrome therapy Treatment triggered viral infections Viral pneumonia [DOI] 10.1007/s11033-022-07822-2 PMC 바로가기
Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell linesArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] Activation affected antibody binding cell line cell types Colon contribute COVID-19 COVID-19 patients described disease epithelial expression galectin-3 global pandemic identify IL-6 IL-6 expression inflammatory cells Intervention lung epithelial marker monoclonal antibody pathophysiology pro-inflammatory cytokine Protein receptor Research SARS-CoV-2 severe cases severe COVID-19 patients severe disease severity stimulate stimulated susceptible cell the cytokine storm therapeutic targets Treatment was reduced [DOI] 10.1038/s41598-022-20852-x PMC 바로가기
Ursolic acid and SARS-CoV-2 infection: a new horizon and perspectiveArticle Published on 2022-10-012022-11-15 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome Anti-inflammatory anti-inflammatory cytokines antioxidant antioxidant effects Antiviral ARDS Complication complications coronavirus COVID-19 Cytokine storm disease-causing disorders dysregulation hyper inflammation immune response Immunity IMPROVE indirect effect inflammatory signaling inhibit lung manifestation mitigate neurological oxidative stress pandemic pandemics. Pathways Perspective pro-inflammatory cytokine pro-inflammatory cytokines progression RAS reactive oxygen specy reduce renin-angiotensin system ROS SARS-CoV-2 SARS-COV-2 infection severe cases syndrome ursolic acid Viral pneumonia [DOI] 10.1007/s10787-022-01038-3 PMC 바로가기
The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factorsArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] 치료제, [키워드] activate activating addition aggregation antiplatelet Blood coagulation factor complex convalescent COVID-19 COVID-19 patients disease severity disorders endothelial injury Factor Gas exchange hypercoagulability hypercoagulable hypercoagulable states Hypoxemia hypoxia immune cells impaired lung function impairment incidence Inflammation Inflammatory mediators inhibiting Intervention intrinsic involved Lung function manifestation marker microvesicle Microvesicles Mild Mortality Phosphatidylserine Platelet platelet activation Platelets promote PROTECT pulmonary permeability pulmonary vasculitis reactivity reducing resulting risk severe cases stages the disease therapy Thromboembolism thrombosis thrombosis. thrombotic event tissue Treatment vessel walls with COVID-19 [DOI] 10.3389/fimmu.2022.955654 PMC 바로가기
Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial CellsArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory disease acute respiratory syndrome addition Analysis analyzed assays Biological Blood coagulation caused cell receptor cells cellular receptors changes in clinical manifestation coronavirus coronavirus disease correlated COVID-19 cytopathic effects damage different time points disease endothelial Endothelial cell endothelial cells Endothelial dysfunction Endothelium exposure expression help HUVECs identify immune response increase in Infection lack mass spectrometry Mild symptom molecular molecular mechanism oxidative stress pandemic pathway Protein proteome proteomic proteomics proteomics. responsible SARS-CoV-2 SARS-CoV-2 entry severe cases severe respiratory failure Specific SUMO2 thrombosis triggered umbilical Vascular [DOI] 10.3390/ijms231810452 PMC 바로가기
Covid-19 in children aged 5-11: Examining the issues surrounding vaccination and public health policyArticle Published on 2022-09-012022-11-16 Journal: Paediatric respiratory reviews [Category] 변종, [키워드] adverse event age association children Complication COVID COVID-19 COVID-19 cases Critical database death deaths detrimental eligible Epidemiology Examining FDA approval Health help hospitalizations Hospitalized information mechanical ventilation moderate morbidity much lower myocarditis occur parent pediatric proportion provided public health risk severe cases vaccination vaccination rate vaccination. variants waning immunity [DOI] 10.1016/j.prrv.2022.03.002 PMC 바로가기
Role of the PD-1 and PD-L1 axis in COVID-19COVID-19에서 PD-1 및 PD-L1 축의 역할Editorial Published on 2022-09-012022-09-11 Journal: Future Microbiology [Category] 바이오마커, [키워드] Abstract adaptive adaptive immune cells COVID-19 COVID-19 patient dysregulated expression immune immune cells immune checkpoint molecules Innate immune cells innate immune cells. Ligand PD-1 PD-L1 Prognostic marker Prognostic markers role SARS-CoV-2 Severe case severe cases therapeutic target therapeutic targets [DOI] 10.2217/fmb-2022-0103 PMC 바로가기 [Article Type] Editorial
Serum stratifin and presepsin as candidate biomarkers for early detection of COVID-19 disease progressionCOVID-19 질병 진행의 조기 검출을위한 후보 바이오 마커로서 혈청 스트라 티핀 및 프리 셉신Article Published on 2022-09-012022-08-31 Journal: Journal of pharmacological sciences [Category] MERS, 바이오마커, 진단, 치료기술, 치료제, [키워드] Biomarker Biomarkers changes in Cohort collected condition COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 progression Critical elevated FIVE Hospitalization independent kallistatin Like lung oxygen oxygen support Patient patients Pneumonia Predictive predictive biomarker Presepsin Prognosis prognosis of patient prognostic biomarker Prognostic biomarkers progression remained reported Serum level serum levels serum sample serum samples Severe case severe cases severe COVID-19 significantly significantly higher Stage stratifin Stratifin. Symptom the patient [DOI] 10.1016/j.jphs.2022.06.002 PMC 바로가기 [Article Type] Article
The role of electrolyte imbalances in predicting the severity of COVID-19 in the hospitalized patients: a cross-sectional study Research Published on 2022-08-302022-10-05 Journal: Scientific Reports [Category] SARS, 치료법, [키워드] age C-reactive protein Coronavirus disease 2019 COVID-19 Critical critical cases cross-sectional CRP cut-off D-dimer Electrolyte electrolyte imbalance examined ferritin Hospitalized hospitalized patient illness Inflammatory marker introduced lactate dehydrogenase LDH Lymphocyte count male median median value moderate parameter Patient patients Potassium predict Sensitivity and specificity severe cases severe group severity severity and prognosis severity of COVID-19 sodium suggested the disease three group were measured with COVID-19 [DOI] 10.1038/s41598-022-19264-8 [Article Type] Research